PHENOTYPIC SCREENING
FOR 3D TUMOR MODELS
Closer to physiology
3D PHENOTYPIC Screening SERVICES
CAPACITIES
- Development of multicellular tumor spheroid models from cell lines or primary cells
- High-throughput screening in 96-well format with 145 +/- 15 spheroids per well
- High-content innovative imaging system dedicated to 96-well plate
- one image per well, 140 spheroids per image = near 14000 spheroids analyzed per plate
- Data processing – G-score : powerful mathematical model that takes into account rank of each spheroid
Key phenotypic assays
diameter, shape, cell death
Soon
Protein localisation
Cytotoxicity
Cell proliferation
Differentiation
DNA damage