PHENOTYPIC SCREENING FOR 3D TUMOR MODELS

Closer to physiology

3D PHENOTYPIC Screening SERVICES

CAPACITIES

  •     Development of multicellular tumor spheroid models from cell lines or primary cells   
  •     High-throughput screening in 96-well format with 145 +/- 15 spheroids per well   
  •     High-content innovative imaging system dedicated to 96-well plate   
  •     one image per well, 140 spheroids per image = near 14000 spheroids analyzed per plate   
  •     Data processing – G-score : powerful mathematical model that takes into account rank of each spheroid  

Key phenotypic assays

diameter, shape, cell death

Soon

Protein localisation Cytotoxicity Cell proliferation Differentiation DNA damage