Expertise in a broad range
of cell-based assays

At Genel, we possess expertise in a broad range of cell-based assays to mimic disease-related phenotypes.

Our cellular biology know-how allows us to determine the most efficient, appropriate assay design. Our proven experience in high-content screening enables us to ensure statistically-assisted assay optimization.

cell-based assay

Transforming your biological questions into phenotypic tests.

Large panel of readouts:

  •     Signal transduction pathways
      
  •     Subcellular components
      
  •     Protein localization
      
  •     Cytotoxicity  
  •     Interferon response
      
  •     Cell proliferation
      
  •     Differentiation
      
  •     DNA damage
      
  •     …customized assays/outputs  
Organelle observation

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Understand muscles’ energy production using organelle observation

Keratinocyte differenciation

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Estimate the level of keratin 18/19 protein to study keratinocyte differentiation

Cell proliferation

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Evaluate EdU incorporation to observe cell proliferation

Cytotoxicyty

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Visualize gamma-H2AX foci to assess DNA damage

Micro RNA visualisation

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Identify the location of the miR let7 using proprietary hybridization

Protein detection

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Study the totipotency of hES cells using protein detection

Cell-based Screening optimization

We are able to estimate the number of replicates and the number of cells that must be analyzed to get a statistically reliable screen. Before each screen, we propose an optimized quote that reduces repetition—and cuts costs.

  •     Save time by capturing only the number of images actually needed
      
  •     Plan ahead for future phenotypic screening conditions
      
  •     Increase your chances of target discovery success  
high-confidence interpretation of biological data
from primary cells and 3d cellular models