Skin-Inflammation is a new explant model that perfectly mimics the inflammation exacerbation that occurs during Atopic Dermatitis (AD).
This model is characterized by an increased expression at gene and protein levels of TSLP and IL18.
This model displayed a repression of Filaggrin and an induction of IL1, TNF, NOD2 at gene level.
Normal condition can be restored by ingredient or final product application