Uncover the detoxification potential of your active ingredient
Urban lifestyle is often associated with regular exposure to air pollution. The polluted air contains harmful molecules such as hydrocarbons or pesticides that weaken the skin barrier. There is a growing demand from customers for efficient detoxifying cosmetics. Dermocosmetic companies need cost-effective and efficient methods to assess the detoxifying potential of their pool of active ingredients, in order to identify the most promising ones.
GENdetox is an integrated test which identifies the active ingredient with the highest ability to activate the detoxification response of the skin cells.
GENdetox methods
This test measures the activity of detoxification response using a Xenobiotic Response Element (XRE) Reporter Vector. The xenobiotic response elements are specific sequences that activate the gene expression upon the binding of the pollutant. The anti-pollution potential of the active ingredient can be visualized by a decrease in detoxification response.
The expression levels of XRE response following an exposure to pollutant samples with or without the application of an active ingredient. The star represents a significant difference as compared to the cells not treated with the active ingredient
Once the most potent active ingredient is identified, a functional test can be applied to study the activity of the different enzymes involved in the detoxification process.
Optimized process that guarantees fast and accurate results in as less as 2 months.
A combination of complementary functional and genomic tests that highlight the seboregulatory activity of the active ingredient.
Accurate results delivered
in as less as 2 months
